21 articles - From Saturday Apr 02 2022 to Friday Apr 08 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Arthritis Care Res (Hoboken) |
Rheumatology Continuing Professional Development for Primary Care Clinicians: A Systematic Review. Published studies of rheumatology-focused CPD are moving towards more interactive teaching modalities and are typically conducted in-person though virtual options for rheumatology-focused CPD should be explored to improve access to CPD. Autoimmune disease is an uncommon topic in CPD and represents an area for future expansion. Efficacy was difficult to assess given that most of the studies assessed for learner satisfaction, knowledge acquisition, or behavior change, whereas only one focused on patient outcomes. |
RCT, clinical trials, retrospective studies, etc…
| Arthritis Care Res (Hoboken) |
Use of Popular Opinion Leader Models to Disseminate Information About Clinical Trials to Black Individuals with Lupus in Two U.S. Cities. By leveraging community-academic partnerships, we developed and implemented a curriculum to promote familiarity with clinical trials, leading to information dissemination by POLs in predominantly Black communities that are under-represented in lupus clinical trials. The program successfully transitioned to a virtual model during the COVID-19 pandemic. |
| Arthritis Res Ther |
Alemtuzumab for refractory primary systemic vasculitis-a randomised controlled dose ranging clinical trial of efficacy and safety (ALEVIATE). In a selected group of refractory vasculitis patients, alemtuzumab led to remission in two thirds of patients at 6 months. Remission was maintained to 12 |
Pathological count of IgG4-positive plasmacytes suggests extraophthalmic involvement and relapse in patients with IgG4-related ophthalmic disease: a retrospective study. Lesions from different ophthalmic sites in IgG4ROD patients have similar counts of IgG4+ and IgG+ plasmacytes. The quantity of pathological IgG4+ plasmacytes corresponded to the serum IgG4 concentration in patients with IgG4ROD and could be meaningful in identifying systemic involvement and predicting subsequent relapse. |
Risk factor analysis of perioperative complications in patients with rheumatoid arthritis undergoing primary cervical spine surgery. ASA-PS and long fusion could be indicators predicting perioperative complications in patients with RA after cervical spine surgery. In addition, cervical spine lesions requiring OC fusion or long fusion and high-dose prednisolone use were suggested to be risk factors for increasing severe complications. |
The impact of tofacitinib on fatigue, sleep, and health-related quality of life in patients with rheumatoid arthritis: a post hoc analysis of data from Phase 3 trials. Tofacitinib and adalimumab generally conferred significant, clinically meaningful improvements in fatigue, sleep, and HRQoL (including vitality) vs placebo through M6, with improvements maintained to M12. M6 correlations between FACIT-F, PROs of sleep, HRQoL, and disease activity underscore the interrelatedness of multiple PROs and disease activity in RA. |
| Arthritis Rheumatol |
Racial Disparities in Renal Outcomes over Time among Hospitalized Children with Systemic Lupus Erythematosus. Significant reductions in ESRD and dialysis occurred over time for children with SLE across al racial and ethnic groups. The lack of corresponding reductions in racial disparities highlights the need for targeted interventions to achieve greater treatment benefit among higher risk groups. |
| Rheumatology (Oxford) |
All-cause and cause-specific mortality in rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis: a nationwide registry study. Even in the era of modern treatments for IJDs, patients with RA and axSpA still have shortened life expectancy. Our findings warrant further attention to the prevention and management of comorbidities. |
Autoimmune disease and COVID-19- a multicentre observational study in the United Kingdom. Patients with severe rheumatologic AD had significantly higher mortality. Anaemia, renal impairment and raised LDH were more frequent in patients with any AD whilst raised CRP and LDH were more frequent in patients with severe rheumatologic AD both of which have been shown to associate with increased mortality in patients with COVID-19. |
Characterization and outcomes of 414 patients with primary SS who developed hematological malignancies. In the largest reported study of hematological malignancies complicating primary SS, we confirm the overwhelming predominance of B cell lymphomas, especially MALT, with the salivary glands being the primary site of involvement. This highly-specific histopathological scenario is linked with the overall good prognosis with a 5-year survival rate of nearly 90%. |
Fibromyalgia, mood disorders, cognitive test results, cognitive symptoms and quality of life in systemic lupus erythematosus. Cognitive symptoms are common in SLE, but there were no associations between cognitive symptoms and objective cognitive dysfunction. Depression, anxiety and fibromyalgia were more consistently associated with patient-reported cognitive symptoms than with objective cognitive dysfunction. These factors al have a significant impact on quality of life. Understanding the discrepancy between patient-reported cognitive symptoms and cognitive test performance is essential to advance care in this area of unmet need. |
Humoral response to Coronavirus Disease-19 vaccines is dependent on dosage and timing of rituximab in patients with rheumatoid arthritis. Both increased time between latest rituximab infusion and complete vaccination and 200 |
Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes. Treatment with the deiodinase inhibitor IOP reduced detrimental changes of injurious mechanical stress. In addition, we identified that its mode of action was likely on metabolic processes, cell proliferation and differentiation. |
Pre-defined gene co-expression modules in rheumatoid arthritis transition towards molecular health following anti-TNF therapy. This study provides independent validation of changes in module expression in response to therapy in RA. However, these effects are not specific to TNFi. Further studies are required to determine whether specific modules could assist molecular classification of therapeutic response. |
Safety and Efficacy of Filgotinib, Lanraplenib, and Tirabrutinib in Sjögren's Syndrome: Randomised, Phase 2, Double-Blind, Placebo-Controlled Study. Three drugs with disparate mechanisms were tested, but no significant differences vs placebo in primary or secondary endpoints were observed. These results may be considered hypothesis-generating, given the drug tolerability, subgroup analysis, and biomarker findings. |
The Impact of Disease Severity Measures on Survival in U.S. Veterans with Rheumatoid Arthritis-Associated Interstitial Lung Disease. Both RA and ILD disease severity measures are independent predictors of survival in RA-ILD. These findings demonstrate the prognostic value of monitoring the systemic features of RA-ILD. |
Plenty of the editorials are available as full text through the publisher website using the provided link
Letters to the editors and authors’ replies
| Arthritis Res Ther |
| Arthritis Rheumatol |
all remaining publications eg case reports, images of the month, etc…